Jun 15, 2026Caloric Restriction

Severe Calorie Restriction Improved Prediabetes—Not Aging

An 8-week low-energy diet rapidly improved prediabetes markers, but its molecular-rejuvenation claim rests on surrogate proteins from only 44 high responders.

calorie restrictionprediabetesweight lossinsulin resistance

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Jun 15, 2026Metabolic Aging

Leg Muscle May Flag Insulin Resistance in Older Adults

Can leg muscle flag metabolic trouble? In older adults, lower-limb muscle mass tracked lower insulin-resistance risk, but it does not prove disease prevention.

insulin resistanceappendicular muscle masslower-limb muscleolder adults

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Mar 27, 2026Hormones

PCOS Causes: What Mendelian Randomization Can—and Can’t—Show

A 2024 Mendelian randomization screen links insulin resistance, inflammation, gut microbes, and iron biology to PCOS risk—with major caveats.

pcosinsulin resistanceadipositygut microbiome

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Mar 27, 2026Nutrition

Dietary Niacin Is Linked to Strength After 40—But Don’t Buy Pills Yet

A large NHANES analysis links food-source niacin with stronger muscles and lower insulin resistance after 40. The supplement evidence is weaker.

nad+niacinnmnmuscle mass

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Mar 26, 2026Nutrition

Vegetarian Diets: Why Quality Matters More Than the Label

Do vegetarian diets improve heart-health markers? The evidence favors LDL and glucose gains, but diet quality, not the label, drives the result.

vegetarian dietldl cholesterolinsulin resistanceapolipoprotein b

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Mar 22, 2026Metabolic Health

Artificial Light at Night and Metabolic Risk: What We Know

Bedroom and outdoor artificial light at night are linked to obesity, metabolic risk, and depression. Here is what the studies show—and cannot prove.

light exposuremetabolic syndromecircadian rhythmsleep disruption

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Mar 21, 2026Nutrition

Gut Microbiome Interventions for Metabolic Disease: What Works

Can synbiotics improve blood sugar and lipids? Review RCT and meta-analysis evidence on probiotics, fiber, low-carb diets, and why FMT needs caution.

gut microbiomesynbioticsprobioticsmetabolic health

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Mar 19, 2026Nutrition

Can Your Neutrophil Count Predict Diabetes Diet Response?

A routine CBC neutrophil count may predict diabetes risk and remission on a Mediterranean diet—but the evidence comes from one heart-disease trial.

neutrophil counttype 2 diabetesmediterranean dietinflammation

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Mar 18, 2026Nutrition

Do BCAAs Cause Insulin Resistance? The Evidence Says No

High protein and BCAAs often get blamed for insulin resistance. Human trials and genetics suggest impaired metabolism usually drives high BCAAs instead.

bcaasprotein intakeinsulin resistancemtor signaling

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Mar 17, 2026Physical Activity

Preventing Gestational Diabetes in High-Risk Pregnancy

Exercise has the clearest RCT evidence for preventing gestational diabetes in high-risk pregnancy. Mediterranean eating may add benefit.

gestational diabetesexerciseglucose disposalglut4

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Mar 17, 2026Sleep

Mediterranean Lifestyle and Sleep Apnea: What Lasts Beyond Weight Loss

A Mediterranean lifestyle improved metabolic health after sleep apnea treatment. Here's what MIMOSA found, where weight loss fits, and what remains unknown.

sleep apneacpapmediterranean dietmetabolic syndrome

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Mar 16, 2026Sleep

Slow-Wave Sleep May Affect Insulin Resistance Before Glucose

A first RCT meta-analysis found disrupted slow-wave sleep raised insulin resistance without raising glucose. What that means—and what remains unproven.

slow-wave sleepinsulin resistancesleep disruptiongrowth hormone

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