Jun 15, 2026Caloric Restriction

Severe Calorie Restriction Improved Prediabetes—Not Aging

An 8-week low-energy diet rapidly improved prediabetes markers, but its molecular-rejuvenation claim rests on surrogate proteins from only 44 high responders.

calorie restrictionprediabetesweight lossinsulin resistance

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Jun 15, 2026Caloric Restriction

Intermittent Fasting Works for Fat Loss, Not Proven Autophagy

Intermittent fasting can help reduce body fat, but human trials show no reliable calorie-independent edge—and claims of whole-body autophagy still outrun proof.

intermittent fastingtime-restricted eatingautophagycalorie restriction

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Apr 29, 2026Nutrition

Time-Restricted Eating After Sleeve Weight Regain: Does It Help?

Can time-restricted eating improve weight regain after sleeve surgery? A close look at the lone direct trial, modest broader evidence, and trade-offs.

time-restricted eatingintermittent fastingcalorie restrictionweight regain

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Mar 28, 2026Nutrition

Calorie Restriction, Taurine, and NLRP3 Inflammaging

A mild calorie deficit raised adipose taurine in a human preprint. Can taurine suppress NLRP3 inflammaging? The mechanism is real; the payoff remains untested.

calorie restrictiontaurinemetabolomicsnlrp3 inflammasome

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Mar 27, 2026Physical Activity

Can Activity Counseling Cut Mortality in Type 2 Diabetes?

A small 11-year diabetes trial linked activity counseling to lower mortality. Why the result is intriguing—and far from settled.

type 2 diabetesexercise interventionmortalitybehavioral counseling

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Mar 27, 2026Nutrition

Calorie Restriction and Muscle mtDNA: What CALERIE Found

The CALERIE trial found that moderate calorie restriction changed muscle gene activity but did not raise mtDNA copy number after two years.

calorie restrictioncalerie trialmitochondrial dnagene expression

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Mar 26, 2026Physical Activity

Cardio, Weights, or Both? Calorie Restriction Evidence

Cardio, weights, or both during calorie restriction? Evidence finds modest differences; fasting timing has not beaten continuous dieting for lipids or BP.

calorie restrictionresistance trainingcardiomixed training

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Mar 26, 2026Nutrition

Meal Timing Works—Mostly Because It Helps You Eat Less

Time-restricted eating can improve weight and metabolic markers, but long-term trials suggest calorie reduction, not the clock, drives most benefits.

intermittent fastingtime-restricted eatingmeal timingcalorie restriction

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Mar 19, 2026Nutrition

Intermittent Fasting and Brain Fog: What Trials Actually Show

Intermittent fasting may improve weight and metabolic markers, but mental-clarity claims outrun human trials, while cognitive side effects remain unmeasured.

intermittent fastingmental claritybrain fogcalorie restriction

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Mar 17, 2026Nutrition

Does Preconception Weight Loss Improve Fertility?

Does weight loss before fertility treatment improve live birth? The best trial found no benefit. Here is what couples should know about diet, exercise, sperm, GLP-1s, and pregnancy.

calorie restrictionfertilityobesitymetabolic syndrome

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Mar 16, 2026Nutrition

Early Time-Restricted Eating vs. Calorie Restriction for Diabetes Risk

A Nature Medicine trial found early time-restricted eating improved glucose tolerance at 6 months, but not 18. What meal timing can and cannot do.

intermittent fastingtime-restricted eatingglucose tolerancecalorie restriction

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Mar 15, 2026Nutrition

Intermittent Fasting vs Mediterranean Diet for Type 2 Diabetes

Intermittent fasting can cut HbA1c quickly in type 2 diabetes, but Mediterranean eating has better long-term evidence. There is no head-to-head trial.

intermittent fastingmediterranean diettype 2 diabeteshba1c

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