Jul 11, 2026Aging Clocks

Can Calorie Restriction Move Biological Aging Metrics?

A two-year randomized calorie-restriction trial moved some aging biomarkers, but mixed clock results show why no test can yet certify slower aging.

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Jul 2, 2026Aging Clocks

Systems Age Maps 11 Body Clocks From One Blood Test

A new DNA methylation test estimates aging across 11 body systems from one blood draw. What Systems Age predicts, and why it cannot guide treatment yet.

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Jun 29, 2026Aging Clocks

DunedinPACE Predicts Health Risk, Not Your Next Move

DunedinPACE tracked disease burden, healthcare-use risk, and mortality in U.S. veterans. What epigenetic aging tests can and cannot tell you.

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Jun 15, 2026Aging Clocks

Multi-Omic Aging Clocks: More Signal, Less Certainty

Multi-omic aging clocks combine methylation, metabolites, and proteins to predict risk more richly. Can they guide personal longevity decisions yet?

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Jun 15, 2026Epigenetic Aging

Childhood Stress and Epigenetic Aging: What Studies Show

Can childhood adversity or depression affect epigenetic aging? Longitudinal studies find a later methylation signal, but not proof of faster aging.

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Jun 15, 2026Aging Clocks

Tape-Strip Skin Clocks: Easier Testing, Unsettled Meaning

Non-invasive tape-strip skin clocks estimate age within about four years. What do small score changes mean for biological aging and health?

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Mar 29, 2026Epigenetics

What Really Drives Biological Aging? Smoking, Diet, and SES

A closer look at biological aging clocks: smoking dominates GrimAge, diet and metabolic health matter, and neighborhood stress may shape aging too.

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Mar 29, 2026Longevity Research

HIV, Epigenetic Aging, and Why ART Leaves a Gut Gap

HIV accelerates epigenetic aging in most studies. ART slows the trend, but gut dysfunction may sustain it—and metformin evidence remains small.

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Mar 29, 2026Epigenetics

Alcohol's Aging Signal May Hide in Whole-Blood Clocks

A monocyte epigenetic clock found alcohol's nonlinear aging signal while whole-blood clocks blurred it. What the evidence can and cannot tell us about biological age.

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Mar 29, 2026Epigenetics

Can Epigenetic Clocks Flag Frailty Before It Starts?

DunedinPACE may track frailty risk from midlife, but meta-analysis favors GrimAge and no epigenetic clock is ready for clinical frailty prediction.

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Mar 28, 2026Epigenetics

Can Lifestyle Changes Turn Back the Epigenetic Clock?

An 8-week lifestyle trial reported a 3.23-year epigenetic-age difference. Larger studies support modest, clock-specific effects instead.

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Mar 28, 2026Physical Activity

Exercise May Methylate Inflammatory Genes in Immune Cells

Exercise changed immune-cell DNA methylation in older women and women with PCOS, but the evidence does not yet prove targeted gene silencing.

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