Jun 15, 2026Aging Clocks

Multi-Omic Aging Clocks: More Signal, Less Certainty

Multi-omic aging clocks combine methylation, metabolites, and proteins to predict risk more richly. Can they guide personal longevity decisions yet?

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Mar 29, 2026Longevity Research

Do Sex Hormones Slow Epigenetic Aging? The Best Test Says No

A 1,404-person study tested estradiol, DHEAS, and testosterone-related measures against six epigenetic clocks. The results were inconsistent.

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Mar 29, 2026Longevity Research

HIV, Epigenetic Aging, and Why ART Leaves a Gut Gap

HIV accelerates epigenetic aging in most studies. ART slows the trend, but gut dysfunction may sustain it—and metformin evidence remains small.

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Mar 29, 2026Epigenetics

Alcohol's Aging Signal May Hide in Whole-Blood Clocks

A monocyte epigenetic clock found alcohol's nonlinear aging signal while whole-blood clocks blurred it. What the evidence can and cannot tell us about biological age.

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Mar 29, 2026Epigenetics

Can Epigenetic Clocks Flag Frailty Before It Starts?

DunedinPACE may track frailty risk from midlife, but meta-analysis favors GrimAge and no epigenetic clock is ready for clinical frailty prediction.

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Mar 12, 2026Epigenetics

Volunteering and Epigenetic Aging: A Promising Link

Does volunteering slow biological aging? Older-adult studies link social purpose to favorable epigenetic clocks, but causation remains unproven so far.

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