Apr 6, 2026Urolithin A: What Human Trials Say About MitophagyUrolithin A may improve muscle function and alter immune-cell profiles, but small trials, short follow-up, and preclinical claims limit certainty.urolithin acd8+ t cellsmitophagyRead article →
Mar 29, 2026Do Sex Hormones Slow Epigenetic Aging? The Best Test Says NoA 1,404-person study tested estradiol, DHEAS, and testosterone-related measures against six epigenetic clocks. The results were inconsistent.epigenetic clockstestosteronedheasRead article →
Mar 29, 2026HIV, Epigenetic Aging, and Why ART Leaves a Gut GapHIV accelerates epigenetic aging in most studies. ART slows the trend, but gut dysfunction may sustain it—and metformin evidence remains small.hivbiological agingdna methylationRead article →
Mar 27, 2026Do Vitamin D and Omega-3 Preserve Muscle After 70?A 3-year trial found vitamin D3, omega-3, and light home exercise did not preserve muscle or activity in healthy adults over 70.vitamin d3omega-3muscle massRead article →
Mar 1, 2026Semaglutide’s COVID Signal in SELECT Needs ScrutinySELECT found semaglutide cut COVID-19 deaths without lowering infection rates. The result is intriguing, but it came from a secondary analysis with major caveats.semaglutideglp-1covid-19Read article →
Feb 25, 2026GLP-1 Beyond Weight Loss: What’s Proven and What’s HypeOral semaglutide is here, but the bigger story is where GLP-1 drugs help beyond weight loss: heart disease, sleep apnea, and possibly the brain.Read article →
Feb 24, 202620 Longevity Papers, 19 Unscored: Worm Science Isn't Health AdviceSomeone submitted 20 longevity papers as evidence for healthspan optimization. 19 were never evaluated. The one that was? A C. elegans worm study rated 3 out of 10.healthspanmitophagypolyphenolsRead article →
Feb 24, 2026GLP-1 Drugs as Longevity Tools: What the Science Actually ShowsGLP-1 drugs have solid heart benefits — the rejuvenation narrative is built on mouse studies and editorial hype. Here's what the evidence actually shows.glp-1ozempicautophagyRead article →
Feb 24, 202620 Longevity Studies, Zero Human Data: What Science Really SaysNMN, senolytics, mTOR, and dietary restriction—20 studies, six mechanisms, eight species. One problem: none of it proves you'll live longer. We break it down.nmnsenolyticslongevityRead article →
Feb 24, 2026Mitochondrial Supplements: What the Mouse Studies Actually ProveFour mitochondrial studies are being sold as longevity breakthroughs. None used human subjects. Here's what SLC25A45, MOTS-c, and Peucedanum actually showed.mitochondriacarnitinemots-cRead article →