Jun 30, 2026Multimorbidity

Muscle Loss and Cognitive Decline May Share Metabolic Roots

Human studies link metabolism, inflammation, gait, muscle loss, and cognition. Here is what the shared-root hypothesis proves—and what it cannot yet prove.

metabolomicsmemory declinegait declineinflammation

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Jun 15, 2026Inflammaging

Inflammaging Markers Still Matter—But They’re Part of a Network

CRP and IL-6 predict worse outcomes in aging studies. New metabolomics research adds context—but not a consumer-ready longevity test.

hs-crpil-6tnf-alphametabolomics

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Mar 29, 2026Nutrition

Hydroxytyrosol Changes Metabolites in Prediabetes—So What?

A small randomized trial maps hydroxytyrosol's effects on inflammatory pathways in prediabetes, but clinical benefits remain unproven.

hydroxytyrosolextra virgin olive oilmetabolomicsprediabetes

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Mar 28, 2026Nutrition

Calorie Restriction, Taurine, and NLRP3 Inflammaging

A mild calorie deficit raised adipose taurine in a human preprint. Can taurine suppress NLRP3 inflammaging? The mechanism is real; the payoff remains untested.

calorie restrictiontaurinemetabolomicsnlrp3 inflammasome

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Mar 16, 2026Nutrition

Can Vitamin D3 Reshape Your Gut Microbiome? RCT Evidence

A 4,000-IU vitamin D3 trial found gut microbiome and metabolite-network shifts, but a baseline imbalance limits what it can prove.

vitamin dgut microbiomebifidobacteriaceaemicrobiome diversity

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