Apr 6, 2026Longevity Research

Urolithin A: What Human Trials Say About Mitophagy

Urolithin A may improve muscle function and alter immune-cell profiles, but small trials, short follow-up, and preclinical claims limit certainty.

urolithin acd8+ t cellsmitophagyimmunosenescence

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Apr 6, 2026Nutrition

Urolithin A in Elite Runners: Recovery Signal, No Performance Proof

Can urolithin A improve elite running performance? The first RCT found recovery signals but no significant gain in VO2max, respiration, or 3000 m time.

urolithin amitophagymitochondrial healthvo2 max

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Mar 22, 2026Neuroprotection

Do GLP-1 Drugs Protect the Brain? The Evidence So Far

Do semaglutide and other GLP-1 drugs lower Parkinson's or Alzheimer's risk? Examine the observational signals, bias tests, and missing trial data.

glp-1 agonistssemaglutideparkinson's diseasealzheimer's disease

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Feb 24, 2026Longevity Research

20 Longevity Papers, 19 Unscored: Worm Science Isn't Health Advice

Someone submitted 20 longevity papers as evidence for healthspan optimization. 19 were never evaluated. The one that was? A C. elegans worm study rated 3 out of 10.

healthspanmitophagypolyphenolsc. elegans

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Feb 24, 2026Mitochondrial Health

Mitochondrial Optimization Claims: What Three Studies Actually Show

Three papers on mitochondria are being cited to push supplements. We read them. Two use mouse gene knockouts. One covers sepsis. None tell you what to do.

mitochondrial quality controlmitophagyagingprotac

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